Accelerating cancer without mutations

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Explaining the Supernova Data without Accelerating Expansion

The 2011 Nobel Prize in Physics was awarded “for the discovery of the accelerating expansion of the Universe through observations of distant supernovae.” However, it is not the case that the type Ia supernova data necessitates accelerating expansion. Since we do not have a successful theory of quantum gravity, we should not assume general relativity (GR) will survive unification intact, especia...

متن کامل

Accelerating weighted random sampling without replacement

Random sampling from discrete populations is one of the basic primitives in statistical computing. This article briefly introduces weighted and unweighted sampling with and without replacement. The case of weighted sampling without replacement appears to be most difficult to implement efficiently, which might be one reason why the R implementation performs slowly for large problem sizes. This p...

متن کامل

The Prevalence of P53 Mutations in Laryngeal Cancer in Kerman

Background &Aims: Laryngeal cancer is the second common cancer of respiratory tract, following the lung cancer. Carcinogenesis is a complex multistage process; molecular genetics has provided the evidence that activation of proto-oncogene and loss or inactivation of tumor suppressor genes (TSG) are involved in a large number of malignancies. One of the earliest significant tumor suppressor gene...

متن کامل

Boldly Targeting Kinases without mutations.

and those arising in the context of viral infections remains to be elucidated. These entities share with MBL the indolent course and the low propensity to progress to overt malignancy. Among the patients followed for 5 years, only 17% of them progressed to clinically overt, splenic B-cell lymphoma of MZ origin, and only 3 needed treatment over the follow-up time. It is likely that CBL-MZ repres...

متن کامل

Cancer megafunds with in silico and in vitro validation: accelerating cancer drug discovery via financial engineering without financial crisis

Advances in financial engineering are radically reshaping the biomedical marketplace. For instance, new methods of pooling diversified drug development programs by placing them in a special purpose vehicle (SPV) have been proposed to create a securitized cancer megafund allowing for debt and equity participation. In this study, we perform theoretical and numerical simulations that highlight the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: eLife

سال: 2019

ISSN: 2050-084X

DOI: 10.7554/elife.45809